Increased neutrophil–lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification

Abstract Background The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed ability predict recurrence such after curative resection patients with these neoplasms. Methods Circulating/systemic neutrophil–lymphocyte, monocyte–lymphocyte, platelet–lymphocyte, and platelet–white cell ratios were evaluated 120 who underwent for neoplasms without synchronous distant metastasis between 2001 2018. Recurrence-free-survival overall survival compared using Kaplan–Meier analysis log-rank tests. Univariate or multivariate analyses, a Cox proportional hazards model, used calculate hazard 95% confidence intervals. Results demonstrated that preoperative neutrophil–lymphocyte ratio, tumor size, European Neuroendocrine Tumor Society TMN venous invasion associated recurrence. optimal ratio cut-off value was 2.62, based on receiver operating characteristic curve analysis. In analysis, higher (HR = 3.49 CI 1.05–11.7; P 0.042) classification 8.81, 1.46–168.2; 0.015) independent predictors. Conclusions circulating/systemic is useful convenient marker neoplasm classification.